Serum Leptin, Adiponectin and Tumor Necrosis Factor (TNF)-α in Hyperlipidemic Rats with/without Concomitant Diabetes Mellitus

摘要

The increasing prevalence of obesity and type 1 diabetes mellitus (DM I) constitute a major global health problem. Adipose tissue regulates energy balance, glucose and lipid metabolism by secretion of adipocytokines such as leptin and tumor necrosis factor alpha (TNF-a). In the present study, Margoni et al. compared the lipid profiles and serum levels of leptin, adiponectin and TNF-a in experimental diabetic models using different dietary manipulations. Their findings implicate that serum levels of leptin, adiponectin and TNF-a may serve as markers of obesity and/or DM 1. Although further work is necessary, the authors suggest these molecules may serve as prognostic indicies in cases of subclinical dyslipidemia/DM I.