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Characterization of Trypanosoma rangeli Strains Isolated in Central and South America: an Overview

机译:在中美洲和南美洲分离的锥虫锥虫菌株的表征:概述

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Trypanosoma rangeli is a hemoflagelate parasite that infects domestic and sylvatic animals, as well as man, in Central and South America. T. rangeli has an overlapping distribution with T. cruzi, the etiological agent of Chagas disease, sharing several animal reservoirs and triatomine vectors. We have isolated T. rangeli strains in the State of Santa Catarina, in southern Brazil, which dramatically increased the distribution area of this parasite. This brief review summarizes several studies comparing T. rangeli strains isolated in Santa Catarina with others isolated in Colombia, Honduras and Venezuela. The different methods used include indirect immunofluorescence and western blot assays, lectin agglutination, isoenzyme electrophoresis and random amplified polymorphic DNA analysis, triatomine susceptibility, in vitro cell infection assays, and mini-exon gene analysis.
机译:锥虫锥虫是一种血鞭毛虫,可感染中美洲和南美洲的家养动物和驯养动物以及人。 T.rangeli与Chagas病的病原体T. cruzi有重叠的分布,共享多个动物储集层和Triatomine载体。我们在巴西南部的圣卡塔琳娜州分离到了T.rangeli菌株,这大大增加了该寄生虫的分布面积。这篇简短的综述总结了几项研究,比较了在圣卡塔琳娜州分离的T.rangeli菌株与在哥伦比亚,洪都拉斯和委内瑞拉分离的其他菌株。所使用的不同方法包括间接免疫荧光和Western印迹测定,凝集素凝集,同工酶电泳和随机扩增的多态性DNA分析,三氢嘧啶敏感性,体外细胞感染测定和小外显子基因分析。

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