Effect of antihypertensive therapy with alpha-methyldopa on umbilical artery Doppler in pregnancies with hypertensive disorders

摘要

Aim To clarify whether applying alpha-methyldopa treatment influencesflow resistance in umbilical cord artery in pregnant womensuffering from hypertensive disorder.Methods In this prospective cross-sectional study a follow-up wasdone for 50 pregnant women with singleton pregnancies between36 and 40 gestation weeks, who had been hospitalized at theGynecology and Obstetrics Department of the Cantonal HospitalZenica, Bosnia and Herzegovina from October 2009 to January2012. Pregnant women were classified in two groups accordingto the level of using alpha-methyldopa in the treatment. For allexpectant mothers, flow in umbilical cord artery was measured,Resistance Index (RI) was determined and values were comparedaccordingly.Results There was a statistically significant difference in valuesof umbilical artery resistance index (UA RI) in terms mother’shypertension (p0.05).Conclusion There was no change in flow resistance in umbilicalcord artery in pregnant women suffering from hypertensive disorder.