Rationale: Intraductal papillomas of the accessory parotid glands are extremely rare benign tumors that are most commonly derived from minor salivary glands and are easily misdiagnosed as other diseases. Studying these lesions by pathology and immunohistochemistry can raise awareness of the disease, reduce the rate of misdiagnosis, and provide more precise treatments. Patient concerns: A 35-year-old man first presented to our hospital with a 6-month history of a painless mass on his left parotid gland. Diagnoses: The patient was diagnosed with intraductal papilloma of the accessory parotid gland by pathology and immunohistochemistry. Interventions: The mass was completely resected. Outcomes: After 2 years of postoperative follow-up, the patient recovered well without recurrence. Lessons: Intraductal papilloma of the accessory parotid gland is very rare, and can easily be misdiagnosed as sialadenoma papilliferum, inverted ductal papilloma, or papillary cystadenoma, among others. It is necessary to analyze its pathology and immunohistochemistry in comparison with other diseases. Early excision and long-term follow-up are necessary to provide optimal treatment and to better understand the pathological processes of intraductal papilloma .
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