Background Idiopathic central precocious puberty (CPP) is rare in boys. The aim was to to analyze the presentation and evaluate the frequency of familial factor in boys with idiopathic CPP. Material and Method Data for 28 boys seen consecutively by the same physician for idiopathic CPP were analyzed. Results Puberty started after seven years in all the boys. The associations were intrauterine growth retardation in two, one of whom had Silver Russell syndrome, bilateral retinal degeneration (one case), epilepsy (one case), cryptorchidism (two cases), and inguinal hernia (two cases). All patients had normal basal plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The LH/FSH peaks ratio after a gonadotropin hormone-releasing hormone (GnRH) test was 1 ng/ml despite shortening the interval between GnRH analogue injections. Conclusions Puberty started after seven years in all cases of idiopathic CPP, suggesting that pubertal onset before this age suggests organic CPP. Almost half the cases had familial early puberty.
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机译：背景特发性中枢性性早熟（CPP）在男孩中很少见。目的是分析特发性CPP男孩的表现并评估其家族因素的发生频率。分析了同一位医生连续针对特发性CPP连续观察的28名男孩的材料和方法数据。结果所有男孩的青春期都在七年后开始。两者之间的关联是子宫内生长迟缓，其中两个患有银罗素综合症，双侧视网膜变性（一例），癫痫症（一例），隐睾症（二例）和腹股沟疝（二例）。所有患者的黄体生成激素（LH）和促卵泡激素（FSH）的基础血浆浓度均正常。促性腺激素释放激素（GnRH）试验后的LH / FSH峰比为1 ng / ml，尽管缩短了GnRH类似物注射之间的间隔。结论在所有特发性CPP病例中，青春期都在7年后开始，表明该年龄之前的青春期发病提示器质性CPP。几乎一半的病例患有家族性青春期早期。
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