T-helper (1) Cytokines Increase During Early Pregnancy in Women With a History of Recurrent Spontaneous Abortion

摘要

Background: The measurement of various cytokines may provide different tools for evaluation of the immune system. The objective of this study was to access the role of the Th1 cytokines (IL-2, IFN-γ, TNF-α, TNF-β) in this phenomenon, and detection of Th1 cytokines in women with RSA.Material/Methods: The control group consisted of 40 women with no history of pregnancy loss. The abortion group comprised of 92 women having at least 3 pregnancy losses. Blood samples from the control group and women with RSA were taken at the end of first trimester of gestational age and at the time of abortion, respectively. Sera were separated and lymphocytes were challenged with PHA. All samples were tested for concentration of Th1 cytokines using ELISA methods.Results: It was found that sera from women with RSA produce higher concentration of TNF-α, TNF-β, and IL-2 in comparison with sera from normal pregnant women (NPW) (P