Association between Interleukin-1β Gene –511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis

摘要

BACKGROUND Interleukin-1β (IL-1β) is an important inflammatory cytokine. The associations between IL-1β gene –511C>T/+3954C>T polymorphisms and aggressive periodontitis (AgP) susceptibility have been conflicting. We therefore conducted a meta-analysis to investigate the association of IL-1β genetic polymorphisms with susceptibility to AgP. MATERIAL AND METHODS PubMed and Embase electronic databases were searched for relevant studies. Odds ratios (ORs) with 95% confidence interval (CIs) were used to assess the association between IL-1β polymorphisms and AgP risk. Heterogeneity, publication bias, and sensitivity analysis were performed to guarantee the statistical power. RESULTS Twenty published studies involving 965 patients and 1234 control subjects were included. No significant association between IL-1β polymorphisms and AgP was found. For –511C>T (T [i]vs.[/i] C: OR=0.966, 95%CI=0.696–1.341, P=0.869; CT [i]vs.[/i] CC: OR=0.936, 95%CI=0.761–1.151; TT [i]vs.[/i] CC: OR=0.892, 95%CI=0.464–1.715, P=0.719; CT+TT [i]vs.[/i] CC: OR=1.026, 95%CI=0.795–1.323; TT [i]vs.[/i] CC+CT: OR=0.864, 95%CI=0.436–1.713). For +3954C>T (T [i]vs.[/i] C: OR=1.069, 95%CI=0.901–1.268; CT [i]vs.[/i] CC: OR=0.921, 95%CI=0.699–1.212; TT[i] vs.[/i] CC: OR=1.064, 95%CI=0.747–1.515; CT+TT [i]vs.[/i] CC: OR=0.990, 95%CI=0.764–1.283; TT [i]vs.[/i] CC+CT: OR=1.229, 95%CI=0.919–1.643). Subgroup analyses were conducted with HWE, ethnicity, and study design, and no significant association was detected. CONCLUSIONS These results demonstrate that IL-1β –511C>T and +3954C>T polymorphisms are not the risk factors for developing AgP.