Effects of using potassium adsorption filters on saline-filled and saline-removed methods for the removal of potassium from red blood cell solutions

摘要

Introduction : Red blood cell (RBC) transfusion places preterm infants with non-oliguria at high risk of cardiac arrest due to hyperkalemia. Potassium adsorption filters (PAFs) can remove potassium from RBCs. The typical protocol for use of PAFs in Japan involves priming the filter with 200 mL of saline and filling the filter with saline However, the resulting dead volume (approximately 80 mL) is unnecessary in preterm infants, because the blood is diluted with saline. As transfusion volumes are generally ~10 mL, small volume-separated packs (30~80 mL each) are prepared for preterm infants. However, we are unable to use PAFs in small volume-separated packs due to the dead volume. In this study, we examined the effects of saline-filled and saline-removed methods of PAFs on the removal of potassium from RBCs.