The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models

摘要

Figure 1. SEA0400 mediated NCX forward mode inhibition in caffeine application experiments. Representative tracings of caffeine-induced Ca2+ transients illustrate the different decay rates in OE (A), hetKO (C) and respective WTs as a direct measure of NCX-mediated Ca2+ removal under basal conditions and during NCX inhibition by SEA0400. Quantification of time to 50% decay (T50) of caffeine-induced Ca2+ transients confirmed increased NCX forward mode function in OE (B) and decreased in hetKO (D), and verified NCX forward mode inhibition by SEA0400 in all investigated groups but to different levels. *p < 0.05 vs. basal; +p < 0.05 OE/hetKO vs. WTOE/WThetKO basal; ANOVA on ranks test.