AxonPacking: An Open-Source Software to Simulate Arrangements of Axons in White Matter

摘要

Figure 1. AxonPacking model (A). Electron microscopy of a ventral region of a rat spinal cord stained with osmium. Since most fibers are running along the spinal cord, axons appear like densely packed disks. Three regions can be identified: gracilis (blue), cuneatus (red) and lateral corticospinal (green). (B). Corresponding Model of the white matter with three compartments: extra-axonal space (gray), myelin sheath (black), intra-axonal (white). Graphical illustration of the gap between axons Δ: the periphery of the center disk is at a distance Δ from the periphery of the other six disks in its neighborhood. (C). Axon diameter distribution is modeled by a Gamma law described by the mean (μ) and standard deviation (σ). (D). Relationship between the g-ratio and the axon diameters.