Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis

摘要

Bioassay-guided fractionation of the antikinetoplastid extract of the brown alga Dictyota spiralis has led to the isolation of spiralyde A ( 1 ), a new dolabellane aldehyde, along with other five known related diterpenes ( 2 – 6 ). Their structures were determined by HRESIMS, 1D and 2D NMR spectroscopy, and comparison with data reported in the literature. The antiparasitic activity of all compounds was evaluated. Spiralyde A ( 1 ) and the known compound 3,4-epoxy-7,18-dolabelladiene ( 2 ) were the most active compounds against Leishmania amazonensis and Trypanosoma cruzi . Spiralyde A ( 1 ) was the most potent compound, comparable to benznidazole, the reference drug for trypanocidal activity.