Effects of 6-months' Exercise on Cardiac Function, Structure and Metabolism in Female Hypertensive Rats–The Decisive Role of Lysyl Oxidase and Collagen III

摘要

Purpose: According to the current therapeutic guidelines of the WHO physical activity and exercise are recommended as first-line therapy of arterial hypertension. Previous results lead to the conclusion, however, that hearts of spontaneously hypertensive rats (SHR) with established hypertension cannot compensate for the haemodynamic stresses caused by long-term exercise. The current study was initiated to investigate the effects of aerobic exercise on the cardiac remodeling as the sole therapeutic measure before and during hypertension became established.