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LncRNAs act as prognostic biomarkers in gastric cancer: A systematic review and meta-analysis

机译:LncRNAs作为胃癌预后的生物标志物:系统评价和荟萃分析

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Gastric cancer (GC) is one of the leading causes of cancer-related death. The 5-year overall survival (OS) rate of patients is extremely low and to find a new marker is urgently needed. Increasing studies indicate that long noncoding RNAs (lncRNAs) are abnormally expressed in GC. However, the results of these studies were conflicting and inconclusive, especially in the aspects of tumor prognosis. Therefore, we performed a systematic review and meta-analysis to investigate the clinical values, including prognosis and clinicopathology of different lncRNAs in GC. A total of 38 studies including 34 on OS, 17 on disease-free survival (DFS), 1 on progression-free survival (PFS), 1 on disease-specific survival (DSS), and 34 on clinicopathological features were identified from the databases. Our results indicated that the levels of lncRNAs were associated with the OS (hazard ratios [HR]=1.44, 95% confidence interval [95% CI]=1.23-1.69, P0.001), PFS (HR=2.32, 95% CI=1.10-5.28, P=0.001) and DSS (HR=2.65, 95% CI=1.53-3.60, P=0.009). However, there was no relationship between lncRNAs and DFS (HR=1.25, 95% CI=0.90-1.74, P=0.11). Moreover, lncRNAs were related to lymph node metastasis (odds ratios [OR]=1.67, 95% CI=1.21-2.31, P=0.002) and TNM (OR=1.93, 95% CI=1.27-2.92, P0.001). In conclusion, our present meta-analysis indicated that lncRNAs could function as potential prognostic markers in GC.
机译:胃癌(GC)是与癌症相关的死亡的主要原因之一。患者的5年总生存率(OS)极低,因此迫切需要寻找新的标志物。越来越多的研究表明,长的非编码RNA(lncRNA)在GC中异常表达。然而,这些研究的结果是矛盾且不确定的,特别是在肿瘤预后方面。因此,我们进行了系统的综述和荟萃分析,以研究临床价值,包括GC中不同lncRNA的预后和临床病理。从数据库中鉴定出总共38项研究,包括关于OS的34项,关于无病生存(DFS)的17项,关于无进展生存(PFS)的1项,针对疾病特异性生存(DSS)的1项以及关于临床病理特征的34项研究。我们的结果表明,lncRNA的水平与OS相关(危险比[HR] = 1.44,95%置信区间[95%CI] = 1.23-1.69,P <0.001),PFS(HR = 2.32,95%CI) = 1.10-5.28,P = 0.001)和DSS(HR = 2.65,95%CI = 1.53-3.60,P = 0.009)。但是,lncRNA与DFS之间没有关系(HR = 1.25,95%CI = 0.90-1.74,P = 0.11)。此外,lncRNA与淋巴结转移有关(奇数比[OR] = 1.67,95%CI = 1.21-2.31,P = 0.002)和TNM(OR = 1.93,95%CI = 1.27-2.92,P <0.001)。总之,我们目前的荟萃分析表明,lncRNAs可以作为GC中潜在的预后标志物。

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