Analytical data supporting the “theoretical” postmortem redistribution factor (Ft): a new model to evaluate postmortem redistribution

摘要

The concepts of postmortem redistribution (PMR, F ) factor, and “theoretical” PMR (F_(t) ) – based upon a drug's characteristic L/P ratio – have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration. This paper applies recent data describing liver/peripheral blood (L/P) ratios for many commonly detected drugs to assess these models, and provide a ranking of drugs’ propensity for (and degree of) PMR.