A case of suspected poisoning by benzodiazepines is presented in this paper. Toxicological analyses were applied on the blood collected 48 hours after the facts. GC-MS and HPLC-DAD have detected only nordiazepam which was prescribed in the treatment. Therefore, LC-MS/MS has detected lormetazepam and lorazepam (major metabolite of lormetazepam) in addition of nordiazepam. The concentrations of lormetazepam, lorazepam and nordiazepam measured in blood were 6.8, 6.3, and 16.2 ng/mL, respectively. The initial concentration of each drug at the relevant time, has been calculated from these residual concentrations, using an extrapolation approach. According to estimates, only lormetazepam (189 ng/mL) and lorazepam (68 ng/mL), were active at the target moment. A poisoning by lormetazepam was then considered. The more technology we have, the greater chance we have to get an outcome that is favorable to justice.
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机译：本文介绍了一个疑似苯二氮卓中毒的病例。事后48小时对收集的血液进行了毒理学分析。 GC-MS和HPLC-DAD仅检测到治疗中处方的去甲西ze。因此，LC-MS / MS除检测了去甲西ze外，还检测到了氯硝西epa和劳拉西m（氯硝西epa的主要代谢产物）。血液中洛美他西，劳拉西m和去甲西p的浓度分别为6.8、6.3和16.2 ng / mL。已使用外推法从这些残留浓度计算出了每种药物在相关时间的初始浓度。据估计，在目标时刻只有洛美西az（189 ng / mL）和劳拉西m（68 ng / mL）有效。然后考虑了洛美他西中毒。我们拥有的技术越多，获得正义的结果的机会就越大。
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