Galectin-3 Expression in Human Endometrium and Decidua During The Menstrual Cycle and in Gestation

摘要

OBJECTIVE: G3 is one of the members of the lectin family that may be involved in the establishment?of endometrial receptivity by regulating the proliferation and adhesion of endometrial cells. STUDY DESIGN: Immunohistochemical expression of G3 was tested in late secretory phase of the endometrium?(SPE)(n=30), proliferative phase of the endometrium (PPE)(n=34), and decidua (n=41) and?induced abortions in the first trimester. RESULTS: Expression of G3 during the PPE was low; 12 cases were score 1 and 19 cases were score?2 (p0.001). However, among the late SPE, there were 11 cases at score 2, and 15 cases at score 3.?In the decidua expression of G3, 37 cases were score 3 (p0.001). CONCLUSION: There is a significant progression of G3 expression in SPE and gestation. Although during?the PPE expression is considerably lower. This shows that G3 plays an important role in implantation.