Serum Adiponectin Level and Nutritional Status among Coronary Artery Disease Patients

摘要

Background: Central adipose tissue is now considered to be a large endocrine gland secreting a large list of adipokines. Most of these adipokines are atherogenic with the exception of adiponectin. Objectives: To assessment of serum adiponectin level in relation to nutritional status of coronary artery disease (CAD) patients. Material & Methods: A cross-sectional study was carried out on coronary artery patients attending Alexandria University Student Hospital, Egypt. CAD cases of both sexes were interviewed for dietary intake assessment using a food frequency questionnaire and twenty four hour recall methods, body weight, height and waist circumference were measured. Serum adiponectin level was measured using the ALISA technique and lipid profile was estimated. Results: Morbid obesity was very common among female patients and much more prevalent than among male patients, but obesity was not correlated with the level of adiponectin in serum. Serum adiponectin levels were significantly higher in females than in males, and was also significantly higher in smokers. In males adiponectin levels showed a positive correlation with high density lipoprotein cholesterol (HDL-C) levels and a negative one with serum triglycerides (TG) levels. While in females the daily intake of plant fats and the percentage of energy provided from them showed an inverse association with adiponectin levels. Conclusions: Findings are strongly suggestive that adiponectin decreases in males, smokers and patients with high serum TG and high plant fat intake, while increases in females, ex smokers and patients with high HDL-C levels. While not correlated with any of the anthropometric measurements.