Captan (Pesticides)

摘要

Food Safety Commission of Japan (FSCJ) conducted a risk assessment of captan (CAS No. 133-06-2), a phthalimide fungicide, based on results from various studies. Major adverse effects of captan were observed in suppressed body weight, and also in duodenal mucosal hyperplasia in mice. No adverse effect on fertility was detected. Increases in incidence of duodenal adenoma and adenocarcinoma were identified in mice. Negative results were however obtained from a gene mutation assay of the target in transgenic mice. No genotoxicity relevant to human health of captan was recognized in spite of the positive results in vitro . Therefore, a genotoxic mechanism was unlikely involved in the tumor development, and it enabled us to establish a threshold in the assessment. In developmental toxicity studies, captan, at the doses causing maternal toxicity, increased external alterations as well as skeletal and soft tissue alterations in the fetus of rabbits and hamsters. No captan-induced teratogenicity was detected in rats. Captan (parent compound only) was identified as the residue definition for dietary risk assessment in agricultural and livestock products. The lowest no-observed-adverse-effect level (NOAEL) obtained from all the studies was 10?mg/kg bw/day. FSCJ specified an acceptable daily intake (ADI) of 0.1?mg/kg bw/day by applying a safety factor of 100 to the NOAEL. The lowest NOAEL for potential adverse effects of a single oral administration of captan was 30?mg/kg bw/day in a developmental toxicity study in rabbits. FSCJ specified an acute reference dose (ARfD) of 0.3?mg/kg bw, for women who are or may be pregnant, by applying a safety factor of 100 to the NOAEL. In addition, FSCJ specified an ARfD of 3?mg/kg bw, for general population, by applying a safety factor of 100 to the no-observed-effect level (NOEL) of 300?mg/kg bw obtained from a general pharmacology study in mice.