Hyaluronic Acid-Coated Carbon Nonwoven Fabrics as Potential Material for Repair of Osteochondral Defects for medical applications

摘要

Damaged articular cartilage is known to have poor capacity for regeneration. Carbon fibres (CFs) have been widely investigated as cellular growth supports in cartilage tissue engineering. However, the long duration of the process of cartilage restoration limits the applicability of CFs implants in the treatment of cartilage tissue defects. Hyaluronic acid (HA) plays a key role in cartilage tissue development, repair and function. In the present study we focused on the in vitro and in vivo evaluation of two types of carbon nonwoven fabrics: HA modified and non-modified carbon nonwovens. The results of in vitro studies showed that cells attached well and retained their good viability in the carbon nonwoven matrix. The incorporation of hyaluronic acid resulted in the enhancement of cell proliferation. The results of in vivo studies showed a faster process of tissue regeneration in the case of HA modified carbon nonwovens. The results presented indicated that HA-modified carbon materials seem to be a suitable material for the treatment of osteochondral defects.