Evaluation of Anaesthetic Effects of Orally Administered Crude Methanol Seed Extract of Datura metel L. – Bromazepam Combination for Experimental Surgical Exploration in Dogs

摘要

This work was carried out to evaluate the suitability of conducting experimental surgical proceduresunder orally induced anaesthesia with crude methanol seed extract of Datura metel L. - Bromazepamcombination in dogs. Three (3) apparently healthy Nigerian dogs were administered the combinations ofBromazepam at the dose rate of 2mg/kg with crude methanol seed extract of Datura metel L at the dose rate of2.4g/kg. Laparatomy/gastrotomy surgical procedure was carried out during anthesis. The physiologicparameters and some anaesthetic indices of the dogs were evaluated. The induction of sedation/anaesthesiaat 6 minutes, 52 seconds was smooth and devoid of excitement and restlessness, this was followed byprogressive unconsciousness, loss of anal sphincter tone, loss of pupillary light reflex, good skeletal musclerelaxation and mild analgesia. The physiologic parameters assessed included the measurement of heart rate,respiratory rate; rectal temperature and tissue oxygen saturation were within the normal ranges. The combineddosages of the crude methanol seed extract of Datura metel L (2.4 g/kg) and Bromazepam (2 mg/kg)administered orally to the three dogs was found to be inadequate as the three dogs reacted involuntarily whenincision was made on the linear alba to expose the abdominal cavity. In order to maintain humane surgicalprotocol in handling of the dogs in this study, this necessitated the maintenance of anaesthesia withsubcutaneous administration of Ketamine at the dose rate of 15 mg/kg. There was no intraoperativecomplication due to the anaesthetic combinations used for the surgical procedures. All the patients recovereduneventfully from the anaesthesia.