Risk Factors for Short- and Long-Term Outcomes in Children With STEC-HUS/D+ HUS: A Single-Center Experience:

摘要

Background. Hemolytic uremic syndrome (HUS) is one of the common causes for acute kidney injury in childhood. Objective. The goals of our study were to identify risk factors for short-term complications and long-term outcomes of chronic kidney disease (CKD) in Shiga toxin–producing Escherichia coli (STEC)-HUS and other diarrhea positive (D+) HUS. Methods. Retrospective chart review was obtained of 58 pediatric patients treated for STEC-HUS and other D+ HUS between February 2002 and January 2011. Results. Thirty-three patients (56.9%) required dialysis. Dialysis was more likely initiated if a patient was a female (P .012), oliguric (urine output 0.5 mL/kg/h, P .0005), or hemoglobin (HGB) level 10 g/dL (P = .009) at admission. Neurological complications developed only among 5 dialyzed patients (P .042), and were more common if the patient received hemodialysis (HD) compared with peritoneal dialysis (P .0005). CKD was noted during the subsequent follow-up clinic visits in 5 patients (8.6%). Those ...