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Factor analysis models for structuring covariance matrices of additive genetic effects: a Bayesian implementation

机译:构建加性遗传效应协方差矩阵的因子分析模型:贝叶斯实现

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Multivariate linear models are increasingly important in quantitative genetics. In high dimensional specifications, factor analysis (FA) may provide an avenue for structuring (co)variance matrices, thus reducing the number of parameters needed for describing (co)dispersion. We describe how FA can be used to model genetic effects in the context of a multivariate linear mixed model. An orthogonal common factor structure is used to model genetic effects under Gaussian assumption, so that the marginal likelihood is multivariate normal with a structured genetic (co)variance matrix. Under standard prior assumptions, all fully conditional distributions have closed form, and samples from the joint posterior distribution can be obtained via Gibbs sampling. The model and the algorithm developed for its Bayesian implementation were used to describe five repeated records of milk yield in dairy cattle, and a one common FA model was compared with a standard multiple trait model. The Bayesian Information Criterion favored the FA model.
机译:多元线性模型在定量遗传学中越来越重要。在高维规范中,因子分析(FA)可以为构造(共)方差矩阵提供途径,从而减少描述(共)色散所需的参数数量。我们描述了如何在多变量线性混合模型的背景下使用FA来模拟遗传效应。在高斯假设下,正交公共因子结构用于建模遗传效应,因此边际可能性是具有结构化遗传(协)方差矩阵的多元正态。在标准先验假设下,所有完全条件分布都具有封闭形式,并且可以通过Gibbs采样获得联合后验分布的样本。该模型及其针对贝叶斯实现而开发的算法被用来描述5条奶牛产奶量的重复记录,并将一种常见的FA模型与标准的多特征模型进行了比较。贝叶斯信息准则偏爱FA模型。

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