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首页> 外文期刊>G3: Genes, Genomes, Genetics >Genomic-Enabled Prediction of Ordinal Data with Bayesian Logistic Ordinal Regression
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Genomic-Enabled Prediction of Ordinal Data with Bayesian Logistic Ordinal Regression

机译:利用贝叶斯逻辑序数回归对序数数据进行基因组预测

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摘要

Most genomic-enabled prediction models developed so far assume that the response variable is continuous and normally distributed. The exception is the probit model, developed for ordered categorical phenotypes. In statistical applications, because of the easy implementation of the Bayesian probit ordinal regression (BPOR) model, Bayesian logistic ordinal regression (BLOR) is implemented rarely in the context of genomic-enabled prediction [sample size ( n ) is much smaller than the number of parameters ( p )]. For this reason, in this paper we propose a BLOR model using the Pólya-Gamma data augmentation approach that produces a Gibbs sampler with similar full conditional distributions of the BPOR model and with the advantage that the BPOR model is a particular case of the BLOR model. We evaluated the proposed model by using simulation and two real data sets. Results indicate that our BLOR model is a good alternative for analyzing ordinal data in the context of genomic-enabled prediction with the probit or logit link.
机译:到目前为止,开发的大多数具有基因组功能的预测模型都假定响应变量是连续的且呈正态分布。 Probit模型是一个例外,它是为有序的分类表型开发的。在统计应用中,由于容易实现贝叶斯概率序数回归(BPOR)模型,因此在启用基因组的预测的情况下,很少执行贝叶斯逻辑序数回归(BLOR)[样本大小(n)比数字小得多的参数(p)]。因此,在本文中,我们提出了一种使用Pólya-Gamma数据扩充方法的BLOR模型,该模型可产生与BPOR模型的全条件分布相似的Gibbs采样器,并具有BPOR模型是BLOR模型的特殊情况的优势。我们通过使用仿真和两个真实数据集评估了提出的模型。结果表明,在具有Probit或Logit链接的基因组预测的背景下,我们的BLOR模型是分析序数数据的理想选择。

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