Draft Genome Sequences of Clinical Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Strain APS211 and Its Daptomycin-Susceptible Progenitor APS210

David R. Cameron; Jhih-Hang Jiang; Iain J. Abbott; Denis W. Spelman; Anton Y. Peleg

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Draft Genome Sequences of Clinical Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Strain APS211 and Its Daptomycin-Susceptible Progenitor APS210

机译：临床达托霉素不敏感的耐甲氧西林金黄色葡萄球菌菌株APS211和其对达托霉素敏感的祖细胞APS210的基因组序列草案

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To assess the genetic factors contributing to daptomycin resistance in Staphylococcus aureus, the draft genome of a clinically derived daptomycin-nonsusceptible isolate APS211 was generated and compared to the draft sequence of its susceptible progenitor strain APS210. Four genetic differences were identified including a previously described mutation within the mprF gene.

机译：为了评估导致金黄色葡萄球菌达托霉素抗性的遗传因素，产生了临床衍生的达托霉素-非敏感性分离株APS211的基因组草图，并与其易感祖细胞菌株APS210的草图序列进行了比较。确定了四个遗传差异，包括先前在 mprF 基因中描述的突变。 展开▼

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《Genome Announcements》 |2015年第3期|共2页

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David R. Cameron; Jhih-Hang Jiang; Iain J. Abbott; Denis W. Spelman; Anton Y. Peleg;
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中图分类基因工程（遗传工程）;

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1. Draft Genome Sequences of Five Clinical Methicillin-Resistant Staphylococcus aureus Isolates and a Methicillin-Resistant Staphylococcus epidermidis Isolate [J] . Rajesh Kumar Biswas, Marleen M. Kock, Toyin Adelowotan, Genome Announcements . 2015,第4期

机译：五个临床耐甲氧西林金黄色葡萄球菌分离株和耐甲氧西林表皮葡萄球菌分离株的基因组序列草案

2. Draft Genome Sequences of Two Clinical Methicillin-Resistant Staphylococcus aureus Strains Isolated from Healthy Children in Brazil [J] . Suzi P. de Carvalho, Jéssica B. de Almeida, Leandro M. de Freitas, Genome Announcements . 2017,第15期

机译：从巴西健康儿童中分离出的两种临床耐甲氧西林金黄色葡萄球菌菌株的基因组序列草案

3. Complete Genome Sequence of Staphylococcus aureus Z172, a Vancomycin-Intermediate and Daptomycin-Nonsusceptible Methicillin-Resistant Strain Isolated in Taiwan [J] . Feng-Jui Chen, Tsai-Ling Lauderdale, Lih-Shinn Wang, Genome Announcements . 2013,第6期

机译：金黄色葡萄球菌Z172，万古霉素中间和达托霉素不敏感的耐甲氧西林菌株的完整基因组序列，在台湾分离

4. Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. [C] . David Medina, Thomas J. Webster Society for Biomaterials annual meeting and exposition . 2018

机译：金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌（MRSA），大肠杆菌和铜绿假单胞菌制成的具有抗菌特性的生物硒纳米粒子的合成与表征。

5. Characterization of community-acquired methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis, multilocus sequence typing, and Staphylococcal protein A sequencing: Establishing a strain typing database. [D] . Roberts, Jill Carolyne. 2006

机译：通过脉冲场凝胶电泳，多基因座序列分型和葡萄球菌蛋白A测序表征社区获得的耐甲氧西林金黄色葡萄球菌：建立菌株分型数据库。

6. Draft Genome Sequences of Clinical Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Strain APS211 and Its Daptomycin-Susceptible Progenitor APS210 [O] . David R. Cameron, Jhih-Hang Jiang, Iain J. Abbott, 2015

机译：临床达托霉素不敏感的耐甲氧西林金黄色葡萄球菌菌株APS211和其达托霉素敏感的祖细胞APS210的基因组序列草案

7. Draft Genome Sequences of Five Clinical Methicillin-Resistant Staphylococcus aureus Isolates and a Methicillin-Resistant Staphylococcus epidermidis Isolate [O] . Rajesh Kumar Biswas, Marleen M. Kock, Toyin Adelowotan, 2015

机译：五种临床甲氧西蛋白抗金黄色葡萄球菌的基因组序列草案和耐甲氧西林葡萄球菌癫痫

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3. 达托霉素治疗耐甲氧西林金黄色葡萄球菌感染21例 [J] . 徐时方 ,徐建国 ,侯赛妙 . 实用医学杂志 . 2014,第023期

4. 万古霉素、替考拉宁、利奈唑胺、达托霉素对耐甲氧西林金黄色葡萄球菌抗菌活性及药物优弊的研究 [J] . 赵博 ,陈取 ,杜志成 . 中国实用医药 . 2011,第018期

5. 达托霉素高产菌株的选育 [J] . 杨一恭 ,孙新强 ,盛保伟 . 中国化工贸易 . 2020,第002期

6. 玫瑰孢链霉菌中犬尿氨酸酶的克隆表达及其在达托霉素高产菌株构建中的应用 [C] . 李彦杰 ,王磊 ,胡昌华 . 2012年第五届全国微生物遗传学学术研讨会 . 2012

7. 飞秒激光诱变达托霉素高产菌株技术及其机理的研究 [A] . 李海伟 . 2011

1. 一种选育生产达托霉素的玫瑰孢链霉菌菌株的筛选方法及其所得菌株 [P] . 中国专利： CN101892287B . 2015.06.17

2. 一种选育生产达托霉素的玫瑰孢链霉菌菌株的筛选方法及其所得菌株 [P] . 中国专利： CN101892287A . 2010-11-24

3. composition; pharmaceutical composition; combination therapy; medical apparatus; method for administering at least one glycylcycline and at least one heparin; method for the administration of glycylcycline and heparin; method of treating intraabdominal infections with complications (ciai) and cutaneous infections and complications of the cutaneous structure (csssi) caused by gram negative and gram positive pathogens, anaerobic and methicillin-resistant strains and those resistant to staphylococcus aureus ( mssa and mrsa); method of treating intraabdominal infections with complications (ciai) and infections of the cutaneous and complicating skin structure (csssi) caused by gram negative and gram positive pathogens, anaerobic and methicillin-resistant strains of staphylococcus aureus ( mssa and mrsa) in a patient in need; antibiotic administration method; article of manufacture; kit; use of a glycylcillin of formula I or a pharmaceutically acceptable salt thereof; use of a heparin or pha [P] . 外国专利： BRPI0611070A2 . 2010-08-03

机译：组成;药物组合物;联合疗法医疗器械至少一种缩水甘油环素和至少一种肝素的给药方法;甘氨酰环素和肝素的给药方法;治疗由革兰氏阴性和革兰氏阳性病原体，厌氧和耐甲氧西林的菌株以及对金黄色葡萄球菌有抵抗力的菌株（mssa和mrsa）引起的合并症（ciai）和腹腔内感染的并发症（ciai）和皮肤感染以及皮肤结构并发症（csssi）;革兰氏阴性和革兰氏阳性病原体，金黄色葡萄球菌厌氧和耐甲氧西林菌株（mssa和mrsa）引起的并发症（CIAI）和皮肤感染和皮肤复杂结构（CSSS）感染的腹腔内感染的治疗方法;抗生素给药方法;制品;套件式I的糖基西林或其药学上可接受的盐的用途;肝素或相的使用

4. SEQUENCES FOR THE DETECTION AND IDENTIFICATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS MREJ TYPE V STRAINS [P] . 外国专利： CA2899816C . 2018-05-01

机译：耐甲氧西林金黄色葡萄球菌MREJ V型菌株的检测和鉴定序列

5. Methods and sequences for the detection and identification of methicillin-resistant Staphylococcus aureus MREJ type v strains [P] . 外国专利： EP2322663B1 . 2015-03-18

机译：检测和鉴定耐甲氧西林金黄色葡萄球菌MREJ v型菌株的方法和序列

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Draft Genome Sequences of Clinical Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Strain APS211 and Its Daptomycin-Susceptible Progenitor APS210

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