HIV-associated disruption of lung cytokine networks is incompletely restored in asymptomatic HIV-infected Malawian adults on antiretroviral therapy

摘要

The lung is the site most commonly affected by infectious and non-infectious complications of HIV infection [1], even in individuals on effective antiretroviral therapy (ART). HIV infection is associated with lymphocytic alveolitis [2], a condition characterised by the influx of CD8+ T-cells into the alveolar space. This is thought to occur in response to HIV antigens and forms part of the host response to the presence of HIV in the lung [2, 3]. Excessive influx of inflammatory cells in the lung probably leads to tissue damage, disruption of immune cell homeostasis, impaired gas exchange [4] and predisposition to HIV-associated lung complications.Disruption of lung cytokine networks during chronic HIV infection is incompletely restored in individuals on antiretroviral therapy http://ow.ly/klkF30gTtwfThe authors thank all study participants, Marie Kunkeyani, Felistas Kanyandula, Elizabeth Jalisi and staff of MLW and QECH for their support and cooperation during the study.K.C. Jambo, H.C. Mwandumba, D.L. Tembo, R.S. Heyderman, D.G. Russell and T.J. Allain conceived and designed the study; all authors analysed and interpreted that data; K.C. Jambo, H.C. Mwandumba, D.L. Tembo, D.G. Russell and R.S. Heyderman drafted the manuscript for important intellectual content; and all authors gave final approval of the manuscript for publication.