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首页> 外文期刊>EURASIP journal on bioinformatics and systems biology >Fixed Points in Discrete Models for Regulatory Genetic Networks
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Fixed Points in Discrete Models for Regulatory Genetic Networks

机译:调节遗传网络离散模型中的不动点

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摘要

It is desirable to have efficient mathematical methods to extract information about regulatory iterations between genes from repeated measurements of gene transcript concentrations. One piece of information is of interest when the dynamics reaches a steady state. In this paper we develop tools that enable the detection of steady states that are modeled by fixed points in discrete finite dynamical systems. We discuss two algebraic models, a univariate model and a multivariate model. We show that these two models are equivalent and that one can be converted to the other by means of a discrete Fourier transform. We give a new, more general definition of a linear finite dynamical system and we give a necessary and sufficient condition for such a system to be a fixed point system, that is, all cycles are of length one. We show how this result for generalized linear systems can be used to determine when certain nonlinear systems (monomial dynamical systems over finite fields) are fixed point systems. We also show how it is possible to determine in polynomial time when an ordinary linear system (defined over a finite field) is a fixed point system. We conclude with a necessary condition for a univariate finite dynamical system to be a fixed point system.
机译:期望具有有效的数学方法来从基因转录物浓度的重复测量中提取关于基因之间的调控迭代的信息。当动力学达到稳定状态时,一条信息是令人感兴趣的。在本文中,我们开发了能够检测稳态的工具,这些稳态可以通过离散有限动力系统中的固定点建模。我们讨论两个代数模型,一个单变量模型和一个多元模型。我们证明这两个模型是等效的,并且可以通过离散傅里叶变换将一个模型转换为另一个模型。我们给出了线性有限动力系统的一个新的,更笼统的定义,并给出了使该系统成为不动点系统的必要和充分条件,即所有循环的长度均为一。我们将展示如何将广义线性系统的此结果用于确定某些非线性系统(有限域的单项动力系统)何时是不动点系统。我们还将展示当普通线性系统(在有限域上定义)是不动点系统时,如何在多项式时间内确定。我们以单变量有限动力系统为不动点系统的必要条件作为结论。

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