The treatment of crigler-najjar syndrome by blue light as explained by resonant recognition model

摘要

Background The Crigler-Najjar syndrome is extremely rare genetic disease, that is manifested by severe jaundicedue to lack of UDP glucuronosyltransferase 1-A1 (UDP) activity. The main treatment is to use the blue lightphototherapy, during the prolong time, during the day every day. Methods Here, we analyzed human UDP’s correlation with the blue light phototherapy using the nonlinear physico-mathematical model: Resonant Recognition Model (RRM), which proposes that protein activation is electromagnetic in nature within the frequency range of infrared and visible light. Results We found that human UDP’s are characterized by specific RRM frequency that is related to the blue light radiation. This could be the explicit explanation, why phototherapy with the blue light could replace lack of UDP activity. Conclusion However, the blue light treatment is less effective with ageing, due to decrease of the blue lightpenetration through skin. Thus, there is a need for alternative treatments. Here, we propose to design de-novopeptide, using this specific RRM frequency. Such peptide, according to RRM, is proposed to have the samebiological function as UDP glucuronosyltransferase 1-A1 and thus can be used for alternative treatment of Crigler-Najjar syndrome.