INNOVATIVE TECHNOLOGIES: MRI-Based Atlas of the Developing Mouse Brain Debuts

摘要

The mouse is one of the major animal models for toxicologic research, but histologic analyses are notoriously slow, taking a week or longer. A new magnetic resonance imaging (MRI)–based atlas of the developing mouse brain now provides a badly needed baseline for studies of how pollutants and genetic mutations affect brain development in mouse models.1 The atlas traces the development and growth not only of the entire mouse brain and its constituent parts but also of its white matter and connectivity,2 day by day, from embryonic day 12 to postnatal day 80.