Recordings of brain activity in moving rats have found neurons that fire when the rat is at specific locations. These neurons are known as grid cells because their activity produces a grid-like pattern. A separate group of neurons, called head direction cells, represents the rat’s facing direction. Functional magnetic resonance imaging (fMRI) studies that have tracked brain activity in humans as they navigate virtual environments have found similar grid-like and direction-related responses. A recent study showed grid-like responses even if the people being studied just imagined moving around an arena while lying still. Theoretical work suggests that spatially tuned cells might generally be important for our ability to imagine and simulate future events. However, it is not clear whether these location- and direction-responsive cells are active when people do not visualize themselves moving. Bellmund et al. used fMRI to track brain activity in volunteers as they imagined different views in a virtual reality city. Before the fMRI experiment, the volunteers completed extensive training where they learned the layout of the city and the names of its buildings. Then, during the fMRI experiment, the volunteers had to imagine themselves standing in front of certain buildings and facing different directions. Crucially, they did not imagine themselves moving between these buildings. By using representational similarity analysis, which compares patterns of brain activity, Bellmund et al. could distinguish between the directions the volunteers were imagining. Activity patterns in the parahippocampal gyrus (a brain region known to be important for navigation) were more similar when participants were imagining similar directions. The fMRI results also show grid-like responses in a brain area called entorhinal cortex, which is known to contain grid cells. While participants were imagining, this region exhibited activity patterns with a six-fold symmetry, as Bellmund et al. predicted from the characteristic firing patterns of grid cells. The findings presented by Bellmund et al. provide evidence that suggests that grid cells are involved in planning how to navigate, and so support previous theoretical assumptions. The computations of these cells might contribute to other kinds of thinking too, such as remembering the past or imagining future events.
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