Chromosomal Arrangement of AHL-Driven Quorum Sensing Circuits inPseudomonas

摘要

Pseudomonasspp. are able to colonize a large variety of environments due to their wide adaptability which is also associated with anN-acyl homoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). In this article we present a systematic overview of the genomic arrangement patterns of quorum sensing genes found inPseudomonasand compare the topologies with those found in other bacterial genomes. We find that the topological arrangement of QS genes is more variable than previously thought but there are a few unifying features that occur in many of the topological arrangements. We hypothesize that the negative regulators of QS that are often found between the canonicalluxR/ andluxI-family genes may be crucial for stabilizing the output of QS circuits.