ANTIANAPHYLACTIC AND MAST CELL STABILIZATION ACTIVITY OF CYNODON DACTYLON

摘要

The. objective. of. the. present. study. was.to. isolate. antianaphylactic. and. mast.cell.stabilizing. compound. from. Cynodon. dactylon.through.bioassay‐guided. fractionation..The. antianaphylactic. activity.was.evaluated. by.using.compound.48/80.induced.anaphylaxis. and.mast.cell. stabilization. was.studied. by. using. peritoneal. mast. cells. of. rats.. The. possible. an tianaphylactic. and. mast. cell. stabilization. mechanism. was. evaluated. by. using.compound.48/80.induced.mast.cell.activation.and.level.of.nitric. oxide. in.serum,. rat.peritoneal. mast.cells.. The. present. study. indicates.that. the.isolated. Cynodon. dactylon.compound.(CDC).was.potent.and.has.significant.(p<0.01.and.p<0.001). inhibitory. effect.on.compound.48/80.induced.anaphylactic.reaction.and.mast.cell.activation..This.CDC.also.inhibited.significantly,.compound.48/80.induced.increased.level.of.nitric.oxide.in.rat.serum. and. rat. peritoneal. mast. cells.. We. conclude. from. this. study.that.the.isolated.CDC.is.potent.then.disodium.chromoglycate.in. producing.antianaphylactic.activity.through.mast.cell.stabilization.and.inhibition.of.nitric.oxide.synthesis