GLIBENCLAMIDE LOADED SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS): DEVELOPMENT AND OPTIMIZATION

摘要

Objective: The objective of the present study was to develop and characterize self-microemulsifying drug delivery system (SMEDDS) of anti-diabetic drug glibenclamide for filling into liquid filling hard gelatin capsules. Methods: Solubility of glibenclamide was evaluated in various nonaqueous careers that included oils, surfactants, and cosurfactants. Pseudo ternary phase diagrams were constructed to identify the self-microemulsification region. Preliminary screening was carried out to select proper components combination. Glibenclamide SMEDDS was prepared using Peceol (oil), Tween 20 (surfactant), Transcutol P (cosurfactant), and evaluated for self-emulsification property, droplet size, polydispesity index, zeta potential, optical clarity, drug content, in-vitro dissolution study in pH 7.4 phosphate buffer compared with plain glibenclamide and marketed tablet. Results: The optimized glibenclamide SMEDDS composed of 15% Peceol, 44% Tween 20 and 41% Transcutol P with droplet size 81.13 nm, PDI 0.270, zeta potential -55.12 mV and complete drug release within 15 min as compared with marketed tablet and plain glibenclamide, which showed limited dissolution rate. Conclusion: The results from this study demonstrate the potential use of SMEDDS as a means of improving solubility, dissolution, and concomitantly the bioavailability of glibenclamide