EVALUATION.OF.THE.WOUND.HEALING.EFFECT.OF.HERBAL.OINTMENT.FORMULATED.WITH.SALVIA.SPLENDENS.(SCARLET.SAGE).

摘要

The.evaluation.of.wound.healing.effect.of.herbal.ointment.formulated.with.Salvia. splendens.(Scarlet.Sage).embedded.in.the.ointment.bases.having.strength.of. 5%,.10%. ,and.15%. which.have.been.evaluated. in. vivo. using.the.excision.wound. healing.model,. incision.wound. healing. model. . and.various. biochemical.parameters.like. Collagen,. Mucopolysaccarides,DNA. and. Proteins..The. evaluation.of.wound. healing. is. compared.with.that.of.Nitrofurazone.ointment(0.2%. w/w).. Salvia. splendens.was.extracted.using.methanol.and.the.extract.formulated.as.herbal.ointments.. The.herbal.ointments.were.used.to.treat.wounds.inflicted.on.experimental..Albino.Mice..The.wound.healing.effect.of.the.formulations.were.compared.to.that.of.a.standard.antibiotic.Nitrofurazone..In.all.cases,.there.as.a.progressive.decrease.in.wound.area.with.time,.indicating.the.efficacy.of.the.formulations.in.healing.the.induced.wounds..By.the.18th.day,.the.ointment.containing.15%.w/w.of.Salvia. splendens.in.ointment.base.showed.100%.healing..The.wound.areas.in.the.animals.treated..with.the.standard.Antibiotics,.Nitrofurazone.showed.a.100%.healing.by.the.18th.day,.indicating.that.the.plant.extract,. at. that. given. concentration,. had. a. better. wound. healing.property.than.the.standard.antibiotic..The.granulation.tissue.weight.and.hydroxyprolline.content.in.the.dead.space.wounds.were.also.increased.significantly,.in.the.herbal.ointment.formulated.with. Salvia.splendens.in.the.treated.animals.as.compared.with.the.standard.antibiotic.Nitrofurazone..treated.animals..