ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF TWENTY-TREE MARINE RED ALGAE FROM THE COAST OF SIDI BOUZID (EL JADIDA-MOROCCO)

摘要

Six organic and aqueous extracts of twenty-three red marine algae collected along the A tlantic coast of Morocco were studied for anti-inflammatory and antimicrobial activities. Anti-inflammatory activity was evaluated as inhibition rate of two enzymes (phospholipase A2 and elastase). Antimicrobial activity was tested against ten gram positive bacteria : Bacillus cereus, Bacillus thuringensis, Bacillus subtillus1 and Bacillus subtillus 2, Clostridium sporogenes, Staphylococcus aureus, Staphylococcus aureus ssp aureus, Mycobacterium smegmatis, Streptococcus feacalis and Bacillus sp, against two gram negative bacteria : Escherichia Coli and Pseudomonas sp and against fungi : Candida tropicalis, Candida albicans and Cryptococcus neoformans. The result shows that 100% of inhibition of phospholipase A2 activity was obtained by Asparagopsis armata, Chondrus crispus and Gelidium sesquipedale extracts, while the inhibition of elastase was obtained with Corallina elongata, Chondrus crispus, Gelidium sesquipedale and Laurencia pinnatifida extracts which give an inhibition greater than 95%. The positive antibacterial activity with diameter inhibition more than 10 mm was found in methanolic and methanol–dichloromethane (50:50) extract. Also, a gram-positive bacteria presents a sensibility superior to the gram-negative and Staphyl ococcus aureus ssp aureus was the more sensitive. The purification and the determination of chemical structure of active compounds from red algae are under investigation