PREPARATION AND EVALUATION OF THE SELF EMULSIFYING DRUG DELIVERY SYSTEM CONTAINING ATORVASTATIN HMG-COA INHIBITER

摘要

As.a.consequence.of.modern.drug.discovery.techniques,.there.has.been.a.steady.increase.in.the.number.of.new.pharmacologically.active.lipophilic.compounds.that.are.poorly.water‐soluble..It.is.a.great.challenge.for.pharmaceutical.scientists.to.convert.those.molecules.into.orally.administered.formulations.with.sufficient.bioavailability..Among.the.approaches.to.improve.the.oral.bioavailability.of.these.molecules,.the.use.of.self‐emulsified.drug. delivery. systems. (SEDDS). has. been. shown. to. be. reasonably. successful. in. improving. the. oral. bioavailability. of. poorly. water‐soluble. and.lipophilic.drugs..In.the.present.study.we.formulate.self‐emulsified. drug. delivery. systems. (SEDDS). through. the. nanoemulsion. for. the. effective.delivery.of.Atorvastatin.which.is.a.HMG‐COA.Inhibiter