FORMULATION OF SUSTAIN RELEASE SOLID DISPERSIONS OF VERAPAMIL HYDROCHLORIDE USING ETHYL CELLULOSE AND EUDRAGIT-RSPO

摘要

A. simple. technique. of. sustained. release. solid. dispersion. (S.D). was. used. in. the. present. investigation. to. control. the. release. of. verapamil.hydrochloride.(VPH).from.tablets.with.ethyl.cellulose. (EC). and. eudragit.RSPO.. In.the.present.study.the.SD's.containing. EC. and. eudragit.RSPO. at.different.drug‐polymer.ratios.of.1:0.5,.1:1,.1:2,.1:3,.1:5,.1:7,.1:7:0.25,.1:7:0.5,.1:7:0.75.as.F1.–VPH:EC,.F2.–.VPH:EC,.F3.–.VPH:EC,.F4.–.VPH:RSPO,.F5.–.VPH:RSPO,.F6.–.VCH:RSPO,.F7.–.VPH:EC:RSPO,.F8.–.VPH:EC:RSPO,.F9.–.VPH:EC:RSPO.respectively.by.solvent.evaporation.technique..The.physical.mixtures.were.prepared.by.physical.mixing.technique.at.the.same.ratio.as.solid.dispersion..FTIR.spectroscopy.suggested.that.there.was.no.major.interaction. between. drug. and. polymers.. The. solid. dispersions. or. physical. mixtures. were. compressed. to. tablets.. All. these. formulations. were.evaluated.by. in-vitro.dissolution.studies.using.USP.apparatus.II.(paddle.method).over.a.period.of.two.hours.in.0.1N.HCl.and.in.pH.6.8.buffer.for.3‐18.hours..The.in‐vitro.drug.release.study.revealed.that.the.S.D's.containing.EC.and.eudragit.RSPO.in.combination.has.extended.the.release.rate.for.20.hours.compared.to.the.physical.mixtures.at.the.same.ratio..The. in‐vitro. release. profile. indicates. that. the. release. of. VPH. can. be. effectively.controlled.from.a.tablet.containing. S.D..The.release.data.was.analysed.as. per.the.peppas. equation.model.indicating.that.the. non‐fickian.diffusion.was.the.release.mechanism