PREPARATION AND EVALUATION OF FLUOXEITINE HYDROCHLORIDE ORAL DISPERSIBLE TABLETS

摘要

The oral route of administration still continue to be the most preferred route due to its manifold advantages including ease of ingestion, pain avoidance, versatility and most importantly patient compliance. Recent advances in novel drug delivery systems aim to enhance safety and efficacy of drug molecule by formulation and to achieve better patient compliance. One such approach is 'mouth dissolving tablets'. Their growing importance was underlined recently when European Pharmacopoeia adopted the term "Orodispersible Tablets" as a tablet that to be placed in the mouth where it disperses rapidly before swallowing. It is one of the fastest growing segments in the pharmaceutical market. The model drug used in the present study is an antidepressant drug used for the handling of unipolar mental depression The present study was aimed to investigate on the best superdisintegrants which is more reliable for the preparation of oral dispersible tablets of Fluoxeitine hydrochloride and it was concluded that the combination of the superdisintegratants (CCS: CP) shows the drug release profile in less time and hence it was concluded that the combination of superdisintegrants was best when compared individually