CHITOSAN BASED SUSTAINED RELEASE MUCOADHESIVE BUCCAL PATCHES CONTAINING VERAPAMIL HCL

摘要

The buccal region of the oral cavity is an attractive target for administration of the drug of choice. Sustained release formulations have been developed and are gaining in popularity and medical acceptance. To increase bioavailability and prevent first pass metabolism of drug, verapamil hydrochloride was embedded in sustained released buccal patch over period of 6 hour. The objective of present work was to characterize the effect of chitosan with PVP K-30 on water soluble drug by preparing mucoadhesive buccal patch. Each formulated batch was subjected to various evaluation parameters. The swelling percentage was found to be function of solubility of drug and PVP K-30. The mucoadhesive strength, vapour transmission and in-vitro released of water soluble drug through water insoluble chitosan base matrix were found satisfactorily. The physical appearance of buccal patch was examined by scanning electron microscopy. The released kinetic model best to fit for the optimized batch was Hixson Crowell, indicating that the drug release from systems in which there is a change in the surface area and the diameter of particles present in dosage form