ACUTE AND CHRONIC ANTI-INFLAMMATORY ACTIVITY OF PERGULARIA DAEMIA WHOLE PLANT IN VARIOUS EXPERIMENTAL ANIMAL MODELS

摘要

Pergularia. daemia.(Asclepiadaceae).has. been. used.widely.to.treat.inflammation.and.pain.in.folklore.medicine..In.the.present.investigation,.acute.and.chronic.anti‐inflammatory.activity. of. petroleum.ether.extract.(PDPE),.ethanolic.extract(PDEE).and.aqueous.extract(PDAE).of.whole.plant.of.Pergularia.daemia.(100,.200.and.400.mg/kg).have.been.investigated.in.carrageenan‐.and.formalin‐.induced.paw.edema.and.turpentine.oil‐induced.granuloma.pouch.in.rats..Oral.administration.of.PDEE.(200.and.400.mg/kg).significantly.reduced.the.paw.volume.(P.<0.001).at.3h.in.carrageenan.model..The.treatment.of.PDEE.(200.and.400.mg/kg).significantly.reduced.the.volume.of.exudates.(P.<0.001).in.turpentine.oil‐induced.granuloma.pouch. dose. dependently.. Chronic. inflammation. induced. by. formalin. injection. was. significantly. (P. <0.001). inhibited. by. PDEE. (400.mg/kg).as.compared.to.the.control.rats..Diclofenac.(10.mg/kg).was.used.as. reference. drug.. Thus,. the. present.study. shows. that.whole.plant.of.Pergularia.daemia.possess.significant.anti‐inflammatory.activity.and.supports.the.claim.in.traditional.medicine.for.the.treatment.of.inflammatory.conditions..