FABRICATION OF DUAL DRUG LOADED POLYMERIC NANOSUSPENSION: INCORPORATING ANALYTICAL HIERARCHY PROCESS AND DATA ENVELOPMENT ANALYSIS IN THE SELECTION OF A SUITABLE METHOD

摘要

Objective: We intend to fabricate dual drug loaded polymeric nanosuspension to overcome the limitations of curcumin in cancer treatment. Methods: However, there are at least eight methods to prepare polymeric nanosuspension but the selection of a suitable method was a real concern, as the selection of inappropriate method may lead to loss of material resources, financial resources and time of research. For the first time, analytic hierarchy process in combination with data envelopment analysis was used to select a suitable method for the preparation of nanosuspension. Results: Nanoprecipitation was identified as a suitable method and implemented in the preparation of dual drug loaded polymeric nanosuspension containing curcumin and bio-enhancer. The obtained nanosuspension were in the average particle size of 116.4 nanometers with polydispersity index of 0.177 and zeta potential of 36.8 millivolt. Conclusion: The study concludes that the integration of analytical hierarchy process and data envelopment analysis has played a vital role in selecting a suitable method for the preparation of nanosuspension