FORMULATION AND IN VITRO EVALUATION OF NATURAL POLYMERS BASED MICROSPHERES FOR COLONIC DRUG DELIVERY

摘要

The. present. study. describes. development. and. in‐vitro. evaluation.of.natural.polymers.based.MTZ.microspheres. prepared. by. ionotropic. gelation. technique. for. delivering.the.drug.to.colon..The.current.work.aimed.to.evaluate.the.novel.potential.of.ionotropic.gelation.technique.to.produce.natural.polysaccharides. based. microspheres. bearing. MTZ,. a. sparingly. water. soluble. antiamoebic. drug,. with.increasing. entrapment. efficiency. by. gluteraldehyde. which. increasing.crossinking.as.well.as.reduced.swelling. ability. of. formulations. with. given. prolonged. colon. targeting.. The. prepared. microspheres. were.characterized. by. entrapment. efficiency,. particle. size,. micromaritic. properties,. in. vitro. release. behavior,.scanning.electron.microscopy.(SEM),.FTIR.etc..MTZ.loaded.microspheres. shows. high. entrapment.efficiency.(75.2%).. The. in. vitro. drug.release. study. was.done. using. U.S.P.dissolution. rate. test.basket. type.apparatus. in. different. PH.media,.which.was.found.to.be.affected.by.change.in.guar.gum‐alginate. and.glutaraldehyde. concentration.. The. percentage. of. drug. released. after.12.hr.was.increased.up.to.85.73%..The.rate.of.drug.release.followed.by.first.order.kinetics.and.numerical.data.fitted.in.peppas.model..It.is.concluded. that. Metronidazole. loaded.guar.gum‐.alginate.based.microsphere. can. be. used. effectively. for.the.colon.targeting....