THE EFFECT OF HANDING MERCURY DROP ELECTRODE ON DIFFERENTIAL PULSE POLAROGRAPHIC BEHAVIOR AND DETERMINATION OF ROSUVASTATIN IN PURE AND PHARMACEUTICAL TABLETS

摘要

Objective: Developing a simple, accurate and very sensitive differential pulse polarographic method (DPPM) for determination of rosuvastatin (RSV) in pure and tablets dosage forms using handing mercury drop electrode (HMDE). Methods: The DPPM was applied in Na 2 HPO 4 buffer at pH 1.5 using a HMDE in optimal conditions. Results: One redaction peak was observed in the range -929 to -940 mV (E p ). The peak current I p is linear over the ranges 0.9631-192.61 ng. mL -1 ; Which led to increase the sensitivity about ten and hundred times when using SMDE and DME, respectively. The relative standard deviation did not exceed 3.6% and regression analysis showed a good correlation coefficient (R 2 = 0.9998). The limit of detection (LOD) and the limit of quantification (LOQ) were to be 0.112 and 0.34 ng. mL -1 , respectively. The amounts of RSV in different tablet dosage forms were decreases with the time (1.1-1.7% after six months at the end of the validity period). Conclusion: The proposed method was successfully applied to determine very small amounts of RSV (0.9631 ng. mL -1 ) in pure form and in pharmaceutical tablets. Keywords: Differential pulse polarographic method, Handing mercury drop electrode, Rosuvastatin, Pharmaceutical tablets.