首页> 外文期刊>International Journal of Nanomedicine >Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma
【24h】

Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma

机译:水溶性l-半胱氨酸包覆的FePt纳米颗粒作为神经胶质瘤的MRI / CT双重成像造影剂

获取原文
       

摘要

Abstract: Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an l-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.
机译:摘要:纳米颗粒(NPs)有利于将诊断剂输送至脑肿瘤。在这项研究中,我们试图开发一种半胱氨酸包被的FePt(FePt-Cys)NP作为MRI / CT成像造影剂,用于诊断恶性神经胶质瘤。 FePt-Cys NPs通过共还原途径合成,其特征在于透射电子显微镜,高分辨率透射电子显微镜,粉末X射线衍射,傅立叶变换红外光谱和动态光散射。使用不同的神经胶质瘤细胞(C6,SGH44,U251)作为模型评估了FePt-Cys NP的MRI和CT成像能力。此外,使用三种不同的细胞系(ECV304,L929和HEK293)作为模型评估了合成后的FePt-Cys NP的生物相容性。结果表明,FePt-Cys NPs表现出优异的生物相容性和良好的MRI / CT成像能力,从而表明其有望作为双重MRI / CT造影剂用于诊断脑恶性神经胶质瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号