Tandem Synthesis And Antibacterial Studies Of Novel 3-Substituted Tetrahydrobenzo [4,5] Thieno [1,2,4] Triazolo [4,3-B] Pyridazine And 2-(5-(Substituted)-4H-1,2,4-Triazole-3-Yl)-Tetrahydrobenzo [B] Thiophene-3-Carbonitirile Derivatives

摘要

A series of novel 3-substituted tetrahydrobenzo[4,5]thieno[1,2,4]triazolo[4,3-b]pyridazine and 2-(5-(substituted)-4H-1,2,4-triazole-3-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile derivative were synthesized. The structures of all derivatives were characterized by LCMS, 1H NMR 13C NMR spectroscopy. Newly synthesized compounds (8a-8f) and (9a-9h) were subjected for their invitro antibacterial screening against Bacillus substilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli R. solanacearum Among the tested compounds, compounds 7d, 7f and 8f exhibited significant antibacterial activity.