Antenatal Diagnosis of Intrauterine Infection WithCoxsackievirus B3 Associated With Live Birth

摘要

Background:Prior reported cases of stillbirth and neonates infected with enteroviruses suggest transplacentalinfection. We present a case of fetal infection with coxsackievirus B3, diagnosed antenatally and resulting in livebirth.Case:A pregnant woman presented at 26 weeks with fetal tachycardia and non-immune hydrops fetalis.Coxsackievirus B3 was cultured from amniotic fluid. Maternal antibody to coxsackievirus B3 was positive at 1:512. At 32 weeks, the fetus deteriorated and was delivered. Cord blood antibody to coxsackievirus B3 waspositive at a higher titer. Following neonatal death, brain and placental tissues were positive for enterovirusribonucleic acid by polymerase chain reaction.Conclusion:Intrauterine infection by enteroviruses should be considered in the differential diagnosis of nonimmunehydrops fetalis. Antenatal diagnosis of coxsackievirus B3 infection is associated with poor outcome.