Efficacy of Clindamycin Vaginal Ovule (3-Day Treatment) vs.Clindamycin Vaginal Cream (7-Day Treatment) in Bacterial Vaginosis

摘要

Objective:To compare the efficacy and safety of a 3-day regimen of clindamycin vaginal ovules with a 7-dayregimen of clindamycin vaginal cream for the treatment of bacterial vaginosis (BV)Methods:Women with a clinical diagnosis of BV were treated with a 3-day course of clindamycin ovules or a 7-daycourse of clindamycin cream administered intravaginally. Three hundred and eighty-four patients received studydrug and were included in the evaluable patient population (ovule group,n= 204; cream group,n= 180).Assessments included pelvic examination and diagnostic testing. Primary efficacy endpoints were a resolution oftwo of three diagnostic criteria at the first follow-up visit and three of three diagnostic criteria at the second.Results:Cure rates in the evaluable patient population were similar between treatment groups: 53.7% (109/204)for the ovule group and 47.8% (85/180) for the cream group (p= 0.2471, 95% CI– 4.1–16.0%). The mostcommonly reported medical event, vulvovaginal pruritus, had similar incidence in both treatment groups.Conclusions:A 3-day course of clindamycin vaginal ovules is as effective and well-tolerated as a 7-day course ofclindamycin vaginal cream in the treatment of BV.