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Periodontal Disease, Inflammatory Cytokines, and PGE2 in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study

机译:孕妇有早产风险的牙周疾病,炎性细胞因子和PGE2:一项初步研究

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Periodontal disease is an infection that, in pregnant women, can act as a risk factor for preterm delivery by increasing local and systemic inflammatory responses. Objective. To analyze the presence of periodontal disease, proinflammatory cytokines, and prostaglandin E2 (PGE2) in pregnant patients at high risk for preterm delivery. Materials and Methods. Pilot study for a case-control study. We included 46 pregnant patients (23 patients at risk of preterm delivery as cases and 23 patients without risk of preterm delivery as controls). We excluded patients who received periodontal treatment, antibiotics, or antimicrobials over the last 3 months as well as those with infections or diseases such as diabetes or hypercholesterolemia. The patients underwent a periodontal assessment, and their levels of cytokines (interleukin- [IL-] 2, IL-6, IL-10, and tumor necrosis factor- [TNF-] α) and prostaglandin E2 (PGE2) were quantified. Results. Patients with periodontal disease showed higher levels of cytokines (IL-2, IL-6, IL-10, and TNF-α) and PGE2. Patients at high risk for preterm birth showed higher IL levels compared with patients at low risk for preterm delivery. PGE2 increased with the severity of periodontal disease. PGE2 was higher in patients at low risk for preterm delivery, although this difference was not significant. Conclusion. Periodontal disease can increase the systemic inflammatory response as well as the levels of PGE2 and inflammatory cytokines in pregnant patients.
机译:牙周疾病是一种感染,在孕妇中,可通过增加局部和全身性炎症反应而成为早产的危险因素。目的。分析早产高危孕妇中牙周疾病,促炎细胞因子和前列腺素E2(PGE2)的存在。材料和方法。病例对照研究的试点研究。我们纳入了46例怀孕患者(其中23例有早产风险的患者和23例无早产风险的患者作为对照)。我们排除了在过去三个月中接受过牙周治疗,抗生素或抗菌剂以及感染或疾病(例如糖尿病或高胆固醇血症)的患者。对患者进行牙周评估,并对他们的细胞因子(白介素-[IL-] 2,IL-6,IL-10和肿瘤坏死因子-[TNF-]α)和前列腺素E2(PGE2)的水平进行定量。结果。牙周病患者显示较高的细胞因子(IL-2,IL-6,IL-10和TNF-α)和PGE2水平。与早产风险低的患者相比,早产风险高的患者显示出更高的IL水平。 PGE 2随着牙周疾病的严重程度而增加。早产风险低的患者中PGE2较高,尽管这种差异并不明显。结论。牙周疾病可以增加孕妇的全身炎症反应以及PGE2和炎症细胞因子的水平。

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