Chitooligosaccharides Downregulate TLR4/NF-κB/COX-2 Signaling Cascade in Dextran Sulfate Sodium-treated Mice: A Potential Mechanism for the Anti-colitis Effect

Qiaoyun Tong; Yuanping Yang; Zhange Xiong; Zhongyan Li; Wei Yuan; Ting Wang

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Chitooligosaccharides Downregulate TLR4/NF-κB/COX-2 Signaling Cascade in Dextran Sulfate Sodium-treated Mice: A Potential Mechanism for the Anti-colitis Effect

机译：壳寡糖下调硫酸葡聚糖钠治疗小鼠中的TLR4 /NF-κB/ COX-2信号级联：一种抗结肠炎作用的潜在机制。

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Background and Objective: The anti-inflammatory properties of chitooligosaccharides (COS), a new class of marine-derived natural products and functional foods have been well established, but the underlying mechanisms remain unclear. The aim of the present

机译：背景与目的：已经很好地建立了壳寡糖（COS），一类新的海洋来源的天然产物和功能性食品的抗炎特性，但其潜在机制尚不清楚。现在的目的

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《International Journal of Pharmacology》 |2016年第7期|共9页
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Qiaoyun Tong; Yuanping Yang; Zhange Xiong; Zhongyan Li; Wei Yuan; Ting Wang;
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中图分类药学;
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机译：麦角甾醇通过抑制COX-2，MMP-9和NF-κB信号传导减轻硫酸葡聚糖钠诱发的结肠炎的炎症
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机译：通过抑制COX-2，MMP-9和NF-κB信号传导，Ferruginol在小鼠中减轻葡聚糖硫酸钠钠诱导的结肠炎的炎症
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4. Physiological and molecular mechanisms contribute to altered smooth muscle contractility during dextran sodium sulfate-induced colitis in mice. [D] . Valderrama Bonilla, Alexandra. 2008

机译：生理和分子机制有助于在小鼠右旋糖酐硫酸钠诱发的结肠炎期间改变平滑肌收缩力。
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机译：番茄番茄红素提取物可预防脂多糖诱导的NF-κB信号传导，但会加剧NF-κBEGFP小鼠的葡聚糖硫酸钠诱导的结肠炎

Chitooligosaccharides Downregulate TLR4/NF-κB/COX-2 Signaling Cascade in Dextran Sulfate Sodium-treated Mice: A Potential Mechanism for the Anti-colitis Effect

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