Hypolipidaemic and Anti-inflammatory effects of Curcumin versus Atorvastatin in Type 2 Diabetic Patients

摘要

This study aimed to determine the effect of curcumin versus atorvastatin on inflammatory markers and lipid profile in poorly controlled type 2 diabetic patients. Disturbance of lipid metabolism appears to be an early event in the development of type 2 diabetes. This study was carried out on forty eight patients who are poorly controlled type 2 diabetics with dyslipidemia , the patients of both sexes on sulfonylurea (glibenclamide), with age range 35-60 years (46.76 ± 7.89), and have disease duration of 5-10 years,patients were randomly assigned to receive either placebo, atorvastatin , or curcumin daily for 12 weeks. In comparison with a placebo-treated group at corresponding after 12 weeks of treatment, there was a high significant decrease in S. Ch. Was found in Atorvastatin, and Curcumin groups. a significant increase in S. HDL of Atorvastatin and a high significant increase in S. HDL of Curcumin group. Corresponding to S. LDL there was no significant difference in S. LDL of and Curcumin groups and a significant decrease in S. LDL of Atorvastatin group were found. In comparison with a placebo-treated group at corresponding duration, after 12 weeks of treatment, there was no significant difference in S. TNF- α of Atorvastatin group, and a high significant decrease in S. TNF-α of Curcumin groups were seen. Corresponding to S. CRP, in comparison with a placebo-treated group at corresponding duration after 12 weeks of treatment, no significant difference in S. CRP of Atorvastatin group, while a significant decrease in S. CRP of Curcumin groups. In conclusion the administration of 1g of Curcumin powder for 12 weeks to type 2 diabetic patients poorly controlled decreased the levels of inflammatory markers and improved the lipid profile of patients, indicating the beneficial adjuvant effect of cinnamon along with conventional medications used to treat type 2 diabetes mellitus.