Clinicobiological Interrelations between Asthma Severity, Duration of Disease and Some Markers of Allergic Inflammation in Asthmatic Pediatric Population in Annaba (Algeria).

摘要

The aim of this study was to study the relationships between the severity of asthma and associated allergic symptoms with the biological parameters of inflammation. 118 children were recruited: 68 asthmatics aged 2-15 years (sex ratio M/F: 1.72) and 50 healthy children aged 1-15 years (sex ratio M/F: 1.5). A standard questionnaire was completed by their GP. Total IgE levels, total protein, eosinophilia and blood levels of malondialdehyde (MDA) and glutathione peroxidase (GPx) were assayed. Atopic disease was present in 72% of children with asthma, in whose home environment high levels of allergens were found. All biological parameters measured were significantly higher in sick children (33% were in the third level GINA) than those of healthy children. Serum total IgE levels were very highly significantly correlated with asthma severity (p <0.001) and MDA levels (p<0.001) and highly significantly correlated with GPx levels (p <0.01). The allergy score was correlated with eosinophilia only (p <0.05). Atopic disease and an allergenic environment were strongly present in the paediatric population studied. The severity of the disease, proven clinically and through blood markers, is associated with many more allergic symptoms. Asthmatic disease, probably inadequately treated, has been present for a long time.